GenAge entry for IL6 (Homo sapiens)

Gene name (HAGRID: 144)

HGNC symbol: IL6
Aliases: IL-6; BSF2; HGF; HSF; IFNB2
Common name: interleukin 6

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: IL6 is involved in a variety of processes such as development, differentiation, and inflammation [720]. Mice without IL6 have a defective hepatocyte regeneration and develop liver failure [721]. Transgenic mice expressing high levels of IL6 have a reduced growth rate and low levels of IGF1 [722]. Its levels appear to increase with age, possibly associating IL6 with age-related changes, such as chronic inflammatory diseases [717]. Polymorphisms in the human IL6 gene have been linked to age-related diseases, such as cardiovascular diseases [1050], though they have not been associated with longevity [221]. A role for IL6 in human ageing is plausible though largely obscure.

Cytogenetic information

Cytogenetic band: 7p21
Location: 22,727,147 bp to 22,732,002 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001781; neutrophil apoptotic process
GO:0001878; response to yeast
GO:0002384; hepatic immune response
GO:0002446; neutrophil mediated immunity
GO:0002548; monocyte chemotaxis
GO:0002675; positive regulation of acute inflammatory response
GO:0002690; positive regulation of leukocyte chemotaxis
GO:0006469; negative regulation of protein kinase activity
GO:0006953; acute-phase response
GO:0006954; inflammatory response
GO:0006959; humoral immune response

And 94 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005896; interleukin-6 receptor complex
GO:0009897; external side of plasma membrane

Function:

GO:0005125; cytokine activity
GO:0005138; interleukin-6 receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for IL6

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Il6
Rattus norvegicus: Il6

In other databases

LongevityMap

This gene is present as IL6

CellAge

This gene is present as IL6