LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian
Study Design: 722 unrelated subjects (401 women and 321 men, mean age, 62.83±25.30 years; 514 subjects aged <85y, mean age = 49 ± 16 year, and 208 individuals aged from 86 y to 104 y, mean age=96 ± 4) were analyzed to assess the impact of specific IRS-2, IGF1R and UCP2 gene variants with longevity
Conclusions: A IGF1R/Asp-IRS2/Val-UCP2 allele combination was associated with an increased probability to reach extreme old age (OD = 3.185 95% CI, 1.63–6.19; p < 0.0006)

HGNC symbol: IGF1R
Aliases: IGFR; CD221; IGFIR; JTK13
Common name: insulin like growth factor 1 receptor
Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Other longevity studies of this gene: 10
OMIM: 147370
Ensembl: ENSG00000140443
UniProt/Swiss-Prot: C9J5X1_HUMAN
Entrez Gene: 3480
UniGene: 643120
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

Barbieri et al. (2012)