LongevityMap variant
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- 722 unrelated subjects (401 women and 321 men, mean age, 62.83±25.30 years; 514 subjects aged <85y, mean age = 49 ± 16 year, and 208 individuals aged from 86 y to 104 y, mean age=96 ± 4) were analyzed to assess the impact of specific IRS-2, IGF1R and UCP2 gene variants with longevity
- Conclusions
- A IGF1R/Asp-IRS2/Val-UCP2 allele combination was associated with an increased probability to reach extreme old age (OD = 3.185 95% CI, 1.63–6.19; p < 0.0006)
- HGNC symbol
- IGF1R
- Aliases
- IGFR; CD221; IGFIR; JTK13
- Common name
- insulin like growth factor 1 receptor
- Description
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
- Other longevity studies of this gene
- 10
- OMIM
- 147370
- Ensembl
- ENSG00000140443
- UniProt/Swiss-Prot
- C9J5X1_HUMAN
- Entrez Gene
- 3480
- UniGene
- 643120
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-2
- Danio rerio
- igf1ra
- Danio rerio
- igf1rb
- Drosophila melanogaster
- InR
- Mus musculus
- Igf1r
- Rattus norvegicus
- Igf1r
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-2
- A homolog of this gene for Mus musculus is present as Igf1r
- A homolog of this gene for Drosophila melanogaster is present as InR
- GenAge human genes
- This gene is present as IGF1R
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as InR
- A homolog of this gene for Caenorhabditis elegans is present as daf-2
Barbieri et al. (2012)
Other variants which are also part of this study