LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Italian
Study Design
722 unrelated subjects (401 women and 321 men, mean age, 62.83±25.30 years; 514 subjects aged <85y, mean age = 49 ± 16 year, and 208 individuals aged from 86 y to 104 y, mean age=96 ± 4) were analyzed to assess the impact of specific IRS-2, IGF1R and UCP2 gene variants with longevity
Conclusions
A IGF1R/Asp-IRS2/Val-UCP2 allele combination was associated with an increased probability to reach extreme old age (OD = 3.185 95% CI, 1.63–6.19; p < 0.0006)
Identifier
rs2229765
In Other Studies (IDs)
325 2199
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser

Gene details

HGNC symbol
IGF1R
Aliases
IGFR; CD221; IGFIR; JTK13 
Common name
insulin like growth factor 1 receptor 
Description
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Other longevity studies of this gene
10
OMIM
147370
Ensembl
ENSG00000140443
UniProt/Swiss-Prot
C9J5X1_HUMAN
Entrez Gene
3480
UniGene
643120
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
daf-2
Danio rerio
igf1ra
Danio rerio
igf1rb
Drosophila melanogaster
InR
Mus musculus
Igf1r
Rattus norvegicus
Igf1r

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-2
  • A homolog of this gene for Mus musculus is present as Igf1r
  • A homolog of this gene for Drosophila melanogaster is present as InR
GenAge human genes
  • This gene is present as IGF1R
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as InR
  • A homolog of this gene for Caenorhabditis elegans is present as daf-2

References

Barbieri et al. (2012)

Other variants which are also part of this study