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Caenorhabditis elegansGenAge entry for daf-2 (Caenorhabditis elegans)

Gene information (ID: 163)

Symbol
daf-2
Name
abnormal DAuer Formation DAF-2, fork head-related transcription factor (daf-2)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Insulin receptor homolog, regulator of dauer formation

Potential relevance to longevity and/or ageing

Observations
Mutations in the daf-2 gene double adult lifespan.
% change in avg or median lifespan
Lifespan is two-fold higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mutants live more than twice as long as controls. This lifespan extension requires the activity of daf-16.
    % change in avg or median lifespan
    Lifespan is more than twice higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mutants show increased lifespan.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Mutations
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Mutants show a two-fold increase in lifespan.
        % change in avg or median lifespan
        Lifespan is two-fold higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Germline ablation in daf-2 mutants
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          Mutants show a 2-3 fold increase in lifespan.
          % change in avg or median lifespan
          Lifespan is two-three folds higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          Mutations
          Longevity Category
          Anti-Longevity
          Primary reference
            Observations
            RNAi resulted in a 17-22% increase in mean lifespan.
            % change in avg or median lifespan
            Average lifespan is 17-22% higher.
            Lifespan Effect
            Increase
            Genetic Manipulation
            RNA interference
            Longevity Category
            Anti-Longevity
            Primary reference
              Observations
              Post developmental RNAi resulted in a 79% increase in mean lifespan.
              % change in avg or median lifespan
              Average lifespan is 79% higher.
              Lifespan Effect
              Increase
              Genetic Manipulation
              RNA interference
              Longevity Category
              Anti-Longevity
              Primary reference

                In other databases

                GenAge model organism genes
                • A homolog of this gene for Mus musculus is present as Igf1r
                • A homolog of this gene for Drosophila melanogaster is present as InR
                • A homolog of this gene for Mus musculus is present as Insr
                GenAge human genes
                • A homolog of this gene for Homo sapiens is present as IGF1R
                • A homolog of this gene for Homo sapiens is present as INSR
                GenDR gene manipulations
                • A homolog of this gene for Drosophila melanogaster is present as InR
                • This gene is present as daf-2
                LongevityMap
                • A homolog of this gene for Homo sapiens is present as IGF1R
                • A homolog of this gene for Homo sapiens is present as INSR

                Homologs in other organisms

                Danio rerio
                igf1rb
                Danio rerio
                igf1ra
                Danio rerio
                insrb
                Danio rerio
                insra
                Drosophila melanogaster
                InR
                Homo sapiens
                INSRR
                Homo sapiens
                IGF1R
                Homo sapiens
                INSR
                Mus musculus
                Insrr
                Mus musculus
                Igf1r
                Mus musculus
                Insr
                Rattus norvegicus
                Insr
                Rattus norvegicus
                Igf1r
                Rattus norvegicus
                Insrr

                External links

                WormBase
                Search
                Ensembl
                Search
                Entrez Gene
                View on Entrez Gene database (175410)
                Homologues
                Search HomoloGene
                UniProt
                Search
                Internet
                Search Google or Search Google Scholar