LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Chinese (Han)
Study Design: Three SNPs in FOXO1A and three in FOXO3A were analyzed in a sample of 760 centenarians (578 female and 182 male) and 1060 middle-age controls (378 female and 682 male)
Conclusions: All three SNPs in FOXO3A were positively associated with longevity in both genders, even at ages 92-110 (odds ratio [OR] = 1.61–1.73, p = .0002–0.005; dominant model)

HGNC symbol: FOXO3
Aliases: FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
Common name: forkhead box O3
Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 101
OMIM: 602681
Ensembl: ENSG00000118689
UniProt/Swiss-Prot: FOXO3_HUMAN
Entrez Gene: 2309
UniGene: 220950
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

CellAge

Zeng et al. (2010)