LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- The Pro/Ala polymorphism at codon 12 was studied in 222 long-lived subjects and 250 aged subjects
- Conclusions
- A different genotype frequency was observed between long-lived and aged men; no differences were observed in the two age groups of women.
- Identifier
- PPARG
- In Other Studies (IDs)
- 1161
- Cytogenetic Location
- 3p25.2
- UCSC Genome Browser
- View 3p25.2 on the UCSC genome browser
Gene details
- HGNC symbol
- PPARG
- Aliases
- GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
- Common name
- peroxisome proliferator activated receptor gamma
- Description
- This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 601487
- Ensembl
- ENSG00000132170
- UniProt/Swiss-Prot
- D2KUA6_HUMAN
- Entrez Gene
- 5468
- UniGene
- 162646
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sex-1
- Caenorhabditis elegans
- nhr-38
- Danio rerio
- pparg
- Mus musculus
- Pparg
- Rattus norvegicus
- Pparg