LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Identifier
- PPARG
- In Other Studies (IDs)
- 152
- Cytogenetic Location
- 3p25.2
- UCSC Genome Browser
- View 3p25.2 on the UCSC genome browser
Gene details
- HGNC symbol
- PPARG
- Aliases
- GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
- Common name
- peroxisome proliferator activated receptor gamma
- Description
- This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 601487
- Ensembl
- ENSG00000132170
- UniProt/Swiss-Prot
- D2KUA6_HUMAN
- Entrez Gene
- 5468
- UniGene
- 162646
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sex-1
- Caenorhabditis elegans
- nhr-38
- Danio rerio
- pparg
- Mus musculus
- Pparg
- Rattus norvegicus
- Pparg