- Symbol
- Cat
- Aliases
- Cas1; Cs-1; Cas-1; 2210418N07
- Name
- Catalase
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Protects cells from hydrogen peroxide
- Observations
- Overexpression of human catalase targeted to mitochondria extended lifespan by about 20%.
- % change in avg or median lifespan
- Lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- The MCAT strain was found to have reduced severity of age-dependent arteriosclerosis and increased genomic stability, as indicated by a decrease in oxidative stress and mitochondrial deletions in heart and muscle tissues. Median and maximum lifespan were increased about 17-21% compared to wild-type controls
- % change in max lifespan
- Maximum lifespan is about 17-21% higher.
- % change in avg or median lifespan
- Median lifespan is about 17-21% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression in cardiac and skeletal muscles
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Cat
- A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as CAT
- LongevityMap
- A homolog of this gene for Homo sapiens is present as CAT
- Caenorhabditis elegans
- ctl-2
- Caenorhabditis elegans
- ctl-3
- Caenorhabditis elegans
- ctl-1
- Danio rerio
- cat
- Drosophila melanogaster
- Cat
- Drosophila melanogaster
- CG9314
- Homo sapiens
- CAT
- Rattus norvegicus
- Cat
- Saccharomyces cerevisiae
- CTA1
- Schizosaccharomyces pombe
- cta1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (12359)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Cat (Mus musculus)