GenAge entry for smk-1 (Caenorhabditis elegans)
Gene information (ID: 616)
- Symbol
- smk-1
- Name
- suppressor of MEK null
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Stress response
Potential relevance to longevity and/or ageing
- Observations
- RNA interference of smk-1 completely suppressed the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. It only slightly shortened the lifespan of wild-type worms.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNAi led to a 44% decrease in median lifespan in daf-2 background and 21% decrease in lifespan in wild-type background.
- % change in avg or median lifespan
- Lifespan is 21% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenDR gene manipulations
- This gene is present as smk-1
Homologs in other organisms
- Danio rerio
- smek1
- Danio rerio
- PPP4R3B
- Drosophila melanogaster
- flfl
- Homo sapiens
- PPP4R3CP
- Homo sapiens
- PPP4R3B
- Homo sapiens
- PPP4R3A
- Mus musculus
- 4930415L06Rik
- Mus musculus
- 4932429P05Rik
- Mus musculus
- Ppp4r3b
- Mus musculus
- Ppp4r3a
- Rattus norvegicus
- Ppp4r3b
- Rattus norvegicus
- Ppp4r3a
- Rattus norvegicus
- Ppp4r3c
- Saccharomyces cerevisiae
- PSY2
- Schizosaccharomyces pombe
- SPBC216.01c
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (179243)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar