GenAge entry for Fgf23 (Mus musculus)
Gene information (ID: 282)
- Symbol
- Fgf23
- Name
- Fibroblast growth factor 23
- Organism
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Knockouts have a short lifespan and display symptoms of premature ageing ageing-like including kyphosis, muscle wasting, osteopenia, emphysema, uncoordinated movement, atherosclerosis, and atrophy of the intestinal villi, skin, thymus, and spleen.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Lack of Fgf-23 activities results in extensive premature ageing-like features and early mortality of Fgf-23 -/- mice, while restoring the systemic effects of FGF-23 significantly ameliorates these phenotypes, with the resultant effect being improved growth, restored fertility, and significantly prolonged survival of double mutants.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Conditional restoration of Fgf23 activity in Fgf23 knockout mice
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as FGF23
Homologs in other organisms
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (64654)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar