GenAge entry for pbs-5 (Caenorhabditis elegans)
Gene information (ID: 1980)
- Symbol
- pbs-5
- Name
- Proteasome subunit beta type
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Transgenic overexpression of pbs-5, which leads to increased proteasome content, assembly, and activity in worms, results in extension of animal lifespan (~25%). The lifespan extension was accompanied by lower level of lipofuscin, slightly slower developmental timing and defecation rhythms, and increased capacity to enter the stress-resistant dauer larvae form, but no severe physiologic alterations were observed between mutants and wild type controls. Subsequent knock-down of pbs-5 by RNAi abolished the extended lifespan of pbs-5 overexpressing animals.
- % change in avg or median lifespan
- Mean lifespan is approximately 25% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as PSMB8
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Psmb8
- CellAge
- A homolog of this gene for Homo sapiens is present as PSMB5
Homologs in other organisms
- Danio rerio
- psmb5
- Danio rerio
- psmb11b
- Danio rerio
- psmb8a
- Drosophila melanogaster
- Prosbeta5R2
- Drosophila melanogaster
- Prosbeta5
- Drosophila melanogaster
- Prosbeta5R1
- Homo sapiens
- PSMB5
- Homo sapiens
- PSMB8
- Homo sapiens
- PSMB11
- Mus musculus
- Psmb11
- Mus musculus
- Psmb5
- Mus musculus
- Psmb8
- Rattus norvegicus
- Psmb8
- Rattus norvegicus
- Psmb5
- Rattus norvegicus
- Psmb11
- Saccharomyces cerevisiae
- PRE2
- Schizosaccharomyces pombe
- pts1
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173334)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar