GenAge entry for clk-1 (Caenorhabditis elegans)
Gene information (ID: 130)
- Symbol
- clk-1
- Name
- Coenzyme Q7 homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Ubiquinone (coenzyme Q, CoQ) biosynthesis
Potential relevance to longevity and/or ageing
- Observations
- Mutations slow down development and extend lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Primary reference
-
- Observations
- Overexpression of CLK-1 activity in wild-type worms can increase mitochondrial activity, accelerate behavioral rates during aging and shorten lifespan.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- RNAi resulted in a lifespan extension by 40%.
- % change in avg or median lifespan
- Lifespan is 40% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Clk-1 mutants display lifespan extension compared to wild-type.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as COQ7
- GenDR gene manipulations
- This gene is present as clk-1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as COQ7
Homologs in other organisms
- Danio rerio
- coq7
- Drosophila melanogaster
- COQ7
- Homo sapiens
- COQ7
- Mus musculus
- Coq7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (175729)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar