GenAge entry for p53 (Drosophila melanogaster)
Gene information (ID: 489)
- Symbol
- p53
- Aliases
- CG10873; CG31325; CG33336; D-p53; Dm-P53; Dmel\CG33336;
- Name
- CG33336-PA
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Cell cycle regulation, apoptosis, and DNA repair
Potential relevance to longevity and/or ageing
- Observations
- Expression of dominant-negative versions of p53 in adult neurons extended lifespan by 58% in females and 32% in males and increased resistance to genotoxic stress.
- % change in avg or median lifespan
- Female lifespan is 58% higher; male lifespan is 32% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Dominant negative mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Expression of dominant-negative (DN) forms of Dmp53 in adult neurons, but not in muscle or fat body cells, extends median lifespan by 19% and maximum lifespan by 8%. The lifespan of calorie-restricted flies is not further extended by simultaneously expressing DN-Dmp53 in the nervous system, indicating that a decrease in Dmp53 activity may be a part of the CR lifespan-extending pathway in flies. Selective expression of DN-Dmp53 in only the 14 insulin-producing cells (IPCs) in the brain extends lifespan to the same extent as expression in all neurons and this lifespan extension is not additive with CR.
- % change in max lifespan
- Maximum lifespan is 8% higher.
- % change in avg or median lifespan
- Median lifespan is 19% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
In other databases
- GenDR gene manipulations
- This gene is present as p53
Homologs in other organisms
No homologs found
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (2768677)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar