GenAge entry for lin-2 (Caenorhabditis elegans)
Gene information (ID: 410)
- Symbol
- lin-2
- Name
- abnormal cell LINeage
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Encodes a protein belonging to the membrane associated guanylate kinase (MAGUK)
Potential relevance to longevity and/or ageing
- Observations
- RNA interference extends lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- lin-1 inhibits the growth of gld-1 tumors. Up to 30% reduction in mean lifespan in daf-2 and gld-1 double mutant background; no mean lifespan change in daf-2 mutants or wild-type background; no significant changes in the maximum lifespan in all backgrounds except daf-2 and gld-1 double mutant background (40% reduction).
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
- Danio rerio
- caska
- Danio rerio
- caska
- Danio rerio
- caskb
- Drosophila melanogaster
- CASK
- Homo sapiens
- CASK
- Mus musculus
- Cask
- Rattus norvegicus
- LOC100910506
- Rattus norvegicus
- LOC100910506
- Rattus norvegicus
- Cask
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (181400)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar