GenAge entry for dagl-2 (Caenorhabditis elegans)
Gene information (ID: 1930)
- Symbol
- dagl-2
- Name
- DiAcylGlycerol Lipase homolog
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Overexpression of dagl-2 (an ortholog of the fly inaE) extends mean lifespan by up to 13%. Conversely, RNA interference of dagl-2 results in a lifespan decrease of up to 14%, while loss-of-function mutantions result in a shorten lifespan by up to 20%.
- % change in avg or median lifespan
- Mean lifespan is up to 13% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as DAGLB
Homologs in other organisms
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (3565075)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar