- Symbol
- ND75
- Name
- NADH:ubiquinone reductase 75kD subunit precursor
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Mitochondrial perturbation through a weak muscle-specific RNA interference of ND75 increases lifespan and preserves locomotory ability. Contrarly, a strong RNA interference of ND75 in the muscle resulted in a developmental arrest around 2 days after egg deposition, with severe myonuclear disintegration and a severely reduced lifespan.
- % change in max lifespan
- Maximum lifespan is 19% higher.
- % change in avg or median lifespan
- Median lifespan is 15% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as nuo-5
- LongevityMap
- A homolog of this gene for Homo sapiens is present as NDUFS1
- Caenorhabditis elegans
- nuo-5
- Danio rerio
- ndufs1
- Homo sapiens
- NDUFS1
- Mus musculus
- Ndufs1
- Rattus norvegicus
- Ndufs1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (31762)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for ND75 (Drosophila melanogaster)