The Lnk gene and its possible relation to ageing in fruit flies

Gene information (ID: 864)

Symbol: Lnk
Aliases: CG; 17367; CG17367; CG5908; Dmel\CG17367; dSH2B; lnk
Name: CG17367 gene product from transcript CG17367-RC
Organism: Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations

Disruption of dSH2B (lnk) decreases insulin-like signaling and somatic growth in flies, and dSH2B deficiency increased hemolymph carbohydrate levels, whole-body lipid levels, lifespan (in both males and females), and resistance to starvation and oxidative stress. Systemic overexpression of dSH2B results in the opposite phenotypes.

% change in max lifespan

Maximum lifespan is 14% higher in males and 15% higher in females.

% change in avg or median lifespan

Median lifespan is 14% higher in males and 33% higher in females.

Lifespan Effect

Increase

Genetic Manipulation

Mutation

Longevity Category

Anti-Longevity

Primary reference

Observations

Loss of Lnk function results in increased median and maximum lifespan, reduces female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygosity did not result in any significant differences in lifespan in either males or females. Additionally, lifespan extension observed in one of the female homozygous mutant was fully rescued by the introduction of a Lnk genomic rescue construct.

% change in avg or median lifespan

Median female lifespan is up to 14% higher; Median male lifespan is up to 17.5% higher.