LongevityMap Gene
Gene details
- HGNC symbol
- UQCRFS1
- Aliases
- RIP1; RIS1; RISP; UQCR5
- Common name
- ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
- Description
- Cytogenetic Location
- 19q12
- UCSC Genome Browser
- View 19q12 on the UCSC genome browser
- OMIM
- 191327
- Ensembl
- ENSG00000169021
- UniProt/Swiss-Prot
- UCRI_HUMAN
- Entrez Gene
- 7386
- UniGene
- 743307
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- isp-1
- Danio rerio
- uqcrfs1
- Drosophila melanogaster
- RFeSP
- Mus musculus
- Uqcrfs1
- Rattus norvegicus
- Uqcrfs1
- Saccharomyces cerevisiae
- RIP1
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as UQCRFS1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs10420904
- Reference