LongevityMap Gene
Gene details
- HGNC symbol
- STARD13
- Aliases
- DLC2; GT650; ARHGAP37; LINC00464
- Common name
- StAR related lipid transfer domain containing 13
- Description
- This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 13q13.1-q13.2
- UCSC Genome Browser
- View 13q13.1-q13.2 on the UCSC genome browser
- OMIM
- 609866
- Ensembl
- ENSG00000133121
- UniProt/Swiss-Prot
- A0A024RDV4_HUMAN
- Entrez Gene
- 90627
- UniGene
- 156551
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gei-1
- Danio rerio
- stard13a
- Danio rerio
- stard13b
- Drosophila melanogaster
- cv-c
- Mus musculus
- Stard13
- Rattus norvegicus
- Stard13
- Saccharomyces cerevisiae
- LRG1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with both age at death and morbidity-free survival at age 65 years
- Indentifier
- rs4943116
- Reference