LongevityMap Gene
Gene details
- HGNC symbol
- RRAGB
- Aliases
- RAGB; bA465E19.1
- Common name
- Ras related GTP binding B
- Description
- Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- Xp11.21
- UCSC Genome Browser
- View Xp11.21 on the UCSC genome browser
- OMIM
- 300725
- Ensembl
- ENSG00000083750
- UniProt/Swiss-Prot
- RRAGB_HUMAN
- Entrez Gene
- 10325
- UniGene
- 50282
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- raga-1
- Danio rerio
- rraga
- Drosophila melanogaster
- RagA-B
- Mus musculus
- Rragb
- Rattus norvegicus
- LOC108348096
- Rattus norvegicus
- RragB
- Rattus norvegicus
- LOC108348096
- Saccharomyces cerevisiae
- GTR1
- Schizosaccharomyces pombe
- gtr1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GTR1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RRAGB
- Reference