LongevityMap Gene
Gene details
- HGNC symbol
- RBPMS
- Aliases
- HERMES
- Common name
- RNA binding protein with multiple splicing
- Description
- This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
- Cytogenetic Location
- 8p12
- UCSC Genome Browser
- View 8p12 on the UCSC genome browser
- OMIM
- 601558
- Ensembl
- ENSG00000157110
- UniProt/Swiss-Prot
- B4E3T4_HUMAN
- Entrez Gene
- 11030
- UniGene
- 334587
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- mec-8
- Danio rerio
- RBPMS
- Drosophila melanogaster
- cpo
- Mus musculus
- Rbpms
- Rattus norvegicus
- Rbpms
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mec-8
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs7011660
- Reference