LongevityMap Gene
Gene details
- HGNC symbol
- PPP3CA
- Aliases
- CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1
- Common name
- protein phosphatase 3 catalytic subunit alpha
- Description
- Cytogenetic Location
- 4q24
- UCSC Genome Browser
- View 4q24 on the UCSC genome browser
- OMIM
- 114105
- Ensembl
- ENSG00000138814
- UniProt/Swiss-Prot
- A0A0S2Z4B5_HUMAN
- Entrez Gene
- 5530
- UniGene
- 435512
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- tax-6
- Danio rerio
- ppp3ca
- Danio rerio
- ppp3cb
- Drosophila melanogaster
- CanA-14F
- Drosophila melanogaster
- CanA1
- Drosophila melanogaster
- Pp2B-14D
- Mus musculus
- Ppp3ca
- Rattus norvegicus
- Ppp3ca
- Saccharomyces cerevisiae
- CNA1
- Saccharomyces cerevisiae
- CMP2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as tax-6
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian), French
- Study Design
- A haplotype-based fine-mapping study was performed in 653 individuals (456 females, >= 98 years, mean age = 100.8 years) and controls (< 50 years, mean age = 38.6 years). Then, the identified haplotype marker was tested in 564 French (472 females, >= 99 years, mean age = 103.1 years) and 564 controls (18- 70 years, mean age = 51.2 years).
- Conclusions
- Although the association was not replicated in French cohort, there was evidence for statistical distortion in the form of Hardy–Weinberg disequilibrium.
- Indentifier
- rs750032
- Reference