LongevityMap Gene

Gene details

HGNC symbol: PPARG
Aliases: GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
Common name: peroxisome proliferator activated receptor gamma
Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 3p25.2
UCSC Genome Browser: View 3p25.2 on the UCSC genome browser
OMIM: 601487
Ensembl: ENSG00000132170
UniProt/Swiss-Prot: D2KUA6_HUMAN
Entrez Gene: 5468
UniGene: 162646
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: sex-1
Caenorhabditis elegans: nhr-38
Danio rerio: pparg
Mus musculus: Pparg
Rattus norvegicus: Pparg

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Pparg

GenAge human genes

This gene is present as PPARG

CellAge

This gene is present as PPARG

Studies (4)

Significant/Non-significant: 3/1

Study 1

Longevity Association

Population

Study Design

The Pro/Ala polymorphism at codon 12 was studied in 222 long-lived subjects and 250 aged subjects

Conclusions

A different genotype frequency was observed between long-lived and aged men; no differences were observed in the two age groups of women.

Indentifier

Reference

Study 2

Longevity Association

Population

Italian (Southern)

Study Design

A sample of 277 unrelated individuals (>70 years old, mean age, 82.9) was recruited in 2000 and genotyped. On the basis of mortality data collected in 2009, the sample was divided into two groups of subjects surviving over 90 years (long-lived) or not (controls).

Conclusions

The frequency of the PPARG Pro/Ala genotype was significantly higher in the sample of male subjects who died before 90 years of age than in the long-lived, suggesting that carrying the PPARG Pro/Ala genotype may prevent the attainment of advanced age in men only

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Dutch
Study Design: A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
Conclusions: No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
Indentifier

Study 4

Longevity Association

Population

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

Reference