LongevityMap Gene
Gene details
- HGNC symbol
- POLD1
- Aliases
- CDC2; MDPL; POLD; CRCS10
- Common name
- DNA polymerase delta 1, catalytic subunit
- Description
- This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
- Cytogenetic Location
- 19q13.33
- UCSC Genome Browser
- View 19q13.33 on the UCSC genome browser
- OMIM
- 174761
- Ensembl
- ENSG00000062822
- UniProt/Swiss-Prot
- A0A024R4F4_HUMAN
- Entrez Gene
- 5424
- UniGene
- 279413
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- F10C2.4
- Danio rerio
- pold1
- Drosophila melanogaster
- DNApol-delta
- Mus musculus
- Pold1
- Rattus norvegicus
- Pold1
- Saccharomyces cerevisiae
- POL3
- Schizosaccharomyces pombe
- pol3
In other databases
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs2546551
- Reference