LongevityMap Gene

Gene details

HGNC symbol
ORC5 
Aliases
ORC5L; ORC5P; ORC5T; PPP1R117 
Common name
origin recognition complex subunit 5 
Description
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Cytogenetic Location
7q22.1-q22.2
UCSC Genome Browser
View 7q22.1-q22.2 on the UCSC genome browser
OMIM
602331
Ensembl
ENSG00000164815
UniProt/Swiss-Prot
A4D0P7_HUMAN
Entrez Gene
5001
UniGene
432948
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
orc-5
Danio rerio
orc5
Drosophila melanogaster
Orc5
Mus musculus
Orc5
Rattus norvegicus
Orc5
Saccharomyces cerevisiae
ORC5
Schizosaccharomyces pombe
orc5

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
European
Study Design
Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
Conclusions
No SNP was significantly associated with mortality after correcting for multiple testing, but 14 independent SNPs were associated with time to death at a suggestive threshold
Indentifier
rs10259086
Reference