LongevityMap Gene
Gene details
- HGNC symbol
- ORC5
- Aliases
- ORC5L; ORC5P; ORC5T; PPP1R117
- Common name
- origin recognition complex subunit 5
- Description
- The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
- Cytogenetic Location
- 7q22.1-q22.2
- UCSC Genome Browser
- View 7q22.1-q22.2 on the UCSC genome browser
- OMIM
- 602331
- Ensembl
- ENSG00000164815
- UniProt/Swiss-Prot
- A4D0P7_HUMAN
- Entrez Gene
- 5001
- UniGene
- 432948
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- orc-5
- Danio rerio
- orc5
- Drosophila melanogaster
- Orc5
- Mus musculus
- Orc5
- Rattus norvegicus
- Orc5
- Saccharomyces cerevisiae
- ORC5
- Schizosaccharomyces pombe
- orc5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with mortality after correcting for multiple testing, but 14 independent SNPs were associated with time to death at a suggestive threshold
- Indentifier
- rs10259086
- Reference