LongevityMap Gene

Gene details

HGNC symbol: NFKB1
Aliases: p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
Common name: nuclear factor kappa B subunit 1
Description: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Cytogenetic Location: 4q24
UCSC Genome Browser: View 4q24 on the UCSC genome browser
OMIM: 164011
Ensembl: ENSG00000109320
UniProt/Swiss-Prot: A0A024RDJ4_HUMAN
Entrez Gene: 4790
UniGene: 618430
1000 Genomes: 1000 Genomes

GenAge model organism genes

GenAge human genes

GenAge microarray genes

Significant/Non-significant: 1/1

Longevity Association: Non-significant
Population: Greek
Study Design: 307 individuals (190 nonagenarians, 12 centenarians and 105 middle-aged controls) were genotyped for ACE, NFkB, and CETP genetic variants
Conclusions: No significant difference were found between case group and control group for NFkB and CETP
Indentifier

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions: 281 SNPs were found to discriminate between cases and controls
Indentifier