LongevityMap Gene
Gene details
- HGNC symbol
- NETO1
- Aliases
- BCTL1; BTCL1
- Common name
- neuropilin and tolloid like 1
- Description
- This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
- Cytogenetic Location
- 18q22.3
- UCSC Genome Browser
- View 18q22.3 on the UCSC genome browser
- OMIM
- 607973
- Ensembl
- ENSG00000166342
- UniProt/Swiss-Prot
- A0A024R375_HUMAN
- Entrez Gene
- 81832
- UniGene
- 465407
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- neto-1
- Danio rerio
- neto1l
- Danio rerio
- neto1
- Drosophila melanogaster
- Neto
- Mus musculus
- Neto1
- Rattus norvegicus
- Neto1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with mortality after correcting for multiple testing, but 14 independent SNPs were associated with time to death at a suggestive threshold
- Indentifier
- rs12606100
- Reference