LongevityMap Gene

Gene details

HGNC symbol: MTTP
Aliases: ABL; MTP
Common name: microsomal triglyceride transfer protein
Description: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 4q23
UCSC Genome Browser: View 4q23 on the UCSC genome browser
OMIM: 157147
Ensembl: ENSG00000138823
UniProt/Swiss-Prot: B7Z7X3_HUMAN
Entrez Gene: 4547
UniGene: 195799
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: mtp
Drosophila melanogaster: Mtp
Mus musculus: Mttp
Rattus norvegicus: Mttp

Studies (6)

Significant/Non-significant: 1/5

Study 1

Longevity Association: Non-significant
Population: German
Study Design: rs1800591, rs2866164, and Q/H 95 SNPs were examined in 1,039 unrelated individuals between 95 and 109 years of age (mean age, 98.2 years); 373 (36%) of the long-lived participants were centenarians or supercentenarians (mean age, 101.4 years). The sex ratio in the entire sample was 74% females vs. 26% males. A total of 540 control individuals aged between 60 and 75 years (mean age, 67.2 years) were used.
Conclusions: No evidence for association was detected between any of the tested SNPs at the allele or at the genotype level
Indentifier

Study 2

Longevity Association

Non-significant

Population

Study Design

-493G/T and Q95H allele and haplotype frequencies were examined in 379 nonagenarians, 525 of their offspring, and 251 partners of their offspring and in 655 octogenarians and 244 young controls

Conclusions

No association with longevity was found

Indentifier

Reference

Study 3

Longevity Association: Significant
Population: Ashkenazi Jewish
Study Design: 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
Conclusions: A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
Indentifier

Study 4

Longevity Association: Non-significant
Population: English (Oxford)
Study Design: 11 SNPs in the MTTP gene were genotyped in 1451 old people (mean age: 77.9 ± 0.2 years) and 777 controls (30- 50 years, mean age: 40.6 ± 0.2 years) to study association with longevity
Conclusions: MTTP gene variants were not significant association with longevity
Indentifier

Study 5

Longevity Association: Non-significant
Population: American (Caucasian), French
Study Design: A haplotype-based fine-mapping study was performed in 653 individuals (456 females, >= 98 years, mean age = 100.8 years) and controls (< 50 years, mean age = 38.6 years). Then, the identified haplotype marker was tested in 564 French (472 females, >= 99 years, mean age = 103.1 years) and 564 controls (18- 70 years, mean age = 51.2 years).
Conclusions: Although the association was not replicated in French cohort, there was evidence for statistical distortion in the form of Hardy–Weinberg disequilibrium.
Indentifier

Study 6

Longevity Association: Non-significant
Population: Danish
Study Design: 1651 participants in the Danish 1905 cohort study (aged 92-93 years) were genotyped for two SNPs (rs2866164 and Q95H). Furthermore, a group of 575 middle-aged Danish twins (mean age 53.7 years) were tested as a younger control group.
Conclusions: The risk haplotype had no significant survival disadvantage after 6.5 years of follow-up. The distributions of the suggested risk alleles and the resulting haplotypes were not statistically different between the two age cohorts.
Indentifier