LongevityMap Gene
Gene details
- HGNC symbol
- MAP2K1
- Aliases
- CFC3; MEK1; MKK1; MAPKK1; PRKMK1
- Common name
- mitogen-activated protein kinase kinase 1
- Description
- The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 15q22.31
- UCSC Genome Browser
- View 15q22.31 on the UCSC genome browser
- OMIM
- 176872
- Ensembl
- ENSG00000169032
- UniProt/Swiss-Prot
- A4QPA9_HUMAN
- Entrez Gene
- 5604
- UniGene
- 145442
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- mek-2
- Danio rerio
- map2k1
- Drosophila melanogaster
- Dsor1
- Mus musculus
- Map2k1
- Rattus norvegicus
- Map2k1
- Saccharomyces cerevisiae
- PBS2
- Schizosaccharomyces pombe
- byr1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mek-2
- CellAge
- This gene is present as MAP2K1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs1549854
- Reference