LongevityMap Gene
Gene details
- HGNC symbol
- JAK2
- Aliases
- JTK10; THCYT3
- Common name
- Janus kinase 2
- Description
- This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 9p24.1
- UCSC Genome Browser
- View 9p24.1 on the UCSC genome browser
- OMIM
- 147796
- Ensembl
- ENSG00000096968
- UniProt/Swiss-Prot
- A8K910_HUMAN
- Entrez Gene
- 3717
- UniGene
- 656213
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as hop
- GenAge human genes
- This gene is present as JAK2
- CellAge
- This gene is present as JAK2
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs2274471
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs7849191
- Reference