LongevityMap Gene
Gene details
- HGNC symbol
- FOXO6
- Aliases
- Common name
- forkhead box O6
- Description
- Cytogenetic Location
- 1p34.2
- UCSC Genome Browser
- View 1p34.2 on the UCSC genome browser
- OMIM
- 611457
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 100132074
- UniGene
- 559677
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Germany, Italian, Chinese (Han)
- Study Design
- 36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
- Conclusions
- None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.
- Indentifier
- rs11585393
- Reference