LongevityMap Gene

Gene details

HGNC symbol: FOXO4
Aliases: AFX; AFX1; MLLT7
Common name: forkhead box O4
Description: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Cytogenetic Location: Xq13.1
UCSC Genome Browser: View Xq13.1 on the UCSC genome browser
OMIM: 300033
Ensembl: ENSG00000184481
UniProt/Swiss-Prot: FOXO4_HUMAN
Entrez Gene: 4303
UniGene: 584654
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: daf-16
Danio rerio: foxo4
Drosophila melanogaster: foxo
Mus musculus: Foxo4
Rattus norvegicus: Foxo4
Saccharomyces cerevisiae: HCM1
Schizosaccharomyces pombe: sep1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as daf-16
A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Saccharomyces cerevisiae is present as HCM1

GenAge human genes

This gene is present as FOXO4

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Caenorhabditis elegans is present as daf-16

CellAge

This gene is present as FOXO4

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association

Population

Study Design

Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls

Conclusions

SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity

Indentifier

Reference

Study 2

Longevity Association: Non-significant
Population: Germany, Italian, Chinese (Han)
Study Design: 36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
Conclusions: None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.
Indentifier

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier