LongevityMap Gene

Gene details

HGNC symbol: FCGR2A
Aliases: CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1
Common name: Fc fragment of IgG receptor IIa
Description: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Cytogenetic Location: 1q23.3
UCSC Genome Browser: View 1q23.3 on the UCSC genome browser
OMIM: 146790
Ensembl: ENSG00000143226
UniProt/Swiss-Prot: FCG2A_HUMAN
Entrez Gene: 2212
UniGene: 352642
1000 Genomes: 1000 Genomes

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

German

Study Design

The FCGR2A-His131Arg polymorphism was analyzed in a group of 408 German centenarians and two samples of younger Germans aged 60-75 and 18-49 years

Conclusions

No statistically significant differences were observed between the three age groups

Indentifier

FCGR2A-His131Ar

Reference