LongevityMap Gene
Gene details
- HGNC symbol
- EIF4EBP1
- Aliases
- BP-1; 4EBP1; 4E-BP1; PHAS-I
- Common name
- eukaryotic translation initiation factor 4E binding protein 1
- Description
- This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 8p11.23
- UCSC Genome Browser
- View 8p11.23 on the UCSC genome browser
- OMIM
- 602223
- Ensembl
- ENSG00000187840
- UniProt/Swiss-Prot
- 4EBP1_HUMAN
- Entrez Gene
- 1978
- UniGene
- 411641
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Thor
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Thor
- CellAge gene expression
- This gene is present as EIF4EBP1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- EIF4EBP1
- Reference