LongevityMap Gene
Gene details
- HGNC symbol
- ATG4C
- Aliases
- APG4C; AUTL1; AUTL3; APG4-C
- Common name
- autophagy related 4C cysteine peptidase
- Description
- Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1p31.3
- UCSC Genome Browser
- View 1p31.3 on the UCSC genome browser
- OMIM
- 611339
- Ensembl
- ENSG00000125703
- UniProt/Swiss-Prot
- ATG4C_HUMAN
- Entrez Gene
- 84938
- UniGene
- 7353
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- atg-4.2
- Danio rerio
- atg4c
- Drosophila melanogaster
- Atg4b
- Mus musculus
- Atg4c
- Rattus norvegicus
- Atg4c
- Saccharomyces cerevisiae
- ATG4
- Schizosaccharomyces pombe
- atg4
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as atg-4.2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.
- Conclusions
- No SNP was significantly associated with mortality after correcting for multiple testing, but 14 independent SNPs were associated with time to death at a suggestive threshold
- Indentifier
- rs12042640
- Reference