LongevityMap Gene

The common polymorphism of apolipoprotein E (E2, E3, and E4) was examined in 179 Finnish centenarians

Population

Finnish

Study Design

Conclusions

The frequency of the E2 allele was higher and that of the E4 allele lower in the centenarians

Indentifier

Reference

Study 2

Longevity Association

The common polymorphism of apolipoprotein E (E2, E3, and E4) was examined in Finnish nonagenarians

Population

Finnish

Study Design

Conclusions

The frequency of the E4 allele was lower in the nonagenarians than in the middle-aged and young adults

Indentifier

Reference

Study 3

Longevity Association

Isoforms were examined in 407 healthy Swedish individuals, 244 men and 163 women, ages 17 to 86 years

Population

Swedish

Study Design

Conclusions

The E4 frequency decreased with increasing age and was significantly lower in individuals > 60 years of age

Indentifier

Reference

Study 4

Longevity Association

APOE common polymorphism (E2, E3, and E4) was examined in a sample of 228 healthy Italian subjects (124 men and 104 women) aged 18-93

Population

Italian

Study Design

Conclusions

The frequency of E4 decreased with age and was not found in subjects aged 75 and older

Indentifier

Reference

Study 5

Longevity Association

Common polymorphism was examined in 182 women and 100 men aged > 84 years and in 100 boys and 100 girls younger than 17 years

Population

English (Cambridge)

Study Design

Conclusions

Difference between genotypes in the elderly women and the young sample was observed. However, this did not retain significance when the genotype frequencies of the young sample were adjusted to values expected from the allele frequencies on the basis of Hardy-Weinberg equilibrium and compared to observed genotypes in elderly men and women.

Indentifier

Reference

Study 6

Longevity Association

Common polymorphism was examined in 179 persons (28 men and 151 women) aged 100 years and older

Population

Finnish

Study Design

Conclusions

The percentages of E2-allele carriers increased with age, particularly in women. The percentage of carriers of the E4 allele was lower than expected.

Indentifier

Reference

Study 7

Longevity Association

Common polymorphism (E2, E3, and E4) was examined in 560 centenarians and 560 adult controls

Population

French

Study Design

Conclusions

Significant differences were observed between centenarians and controls for allelic and genotypic frequencies. The E4E4 genotype was under-represented in centenarians compared to controls. Centenarians carrying at least one E2 allele or homozygous for E3 were more frequent than controls.

Indentifier

Reference

Study 8

Longevity Association

Chinese (Uighur in Xinjiang)

Population

Study Design

Common polymorphism (E2, E3, and E4) was studied in 164 subjects including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction

Conclusions

There was a statistically significant difference in the E4 allele frequencies among the three groups with the older group showing a lower E4 allele frequency

Indentifier

Reference

Study 9

Longevity Association

Common polymorphism was examined in 70 elderly patients aged 80 years or more

Population

Brazilian

Study Design

Conclusions

No association was observed between the genotypes and longevity, though individuals with the E3E4 genotype had a mean age greater than those with the E3E3 genotype.

Indentifier

Reference

Study 10

Longevity Association

Common polymorphism was examined in 103 centenarians (13 men and 90 women, mean age 102.4 +/- 2.6 years) and in 6435 adults (5008 men and 1427 women) of mean age 50.7 +/- 7.9 years

Population

Korean

Study Design

Conclusions

The frequencies of genotypes and alleles of the centenarians were not significantly different from those of the control groups. The frequency of the E4 allele, however, was significantly higher in centenarians with dementia than in centenarians without definitive dementia.

Indentifier

Reference

Study 11

Longevity Association

Common polymorphism was examined in 97 elderly subjects and control group aged 25-64

Population

Russian (Novosibirsk)

Study Design

Conclusions

In men aged 83 years and older the frequency of the E3/E4 genotype was lower and that of the E2/E3 genotype was higher. In subjects of senile age and long-livers of both sexes genotype E4/E4 was not found.

Indentifier

Reference

Study 12

Longevity Association

Ashkenazi Jewish (Jerusalem)

Population

Study Design

Common polymorphism was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and in a group of 441 younger subjects (22 years)

Conclusions

Ashkenazi older subjects were characterized by an increased percentage of the E2 allele and a decreased percentage of the E4 allele, though this was not significant after correcting for multiple testing

Indentifier

Reference

Study 13

Longevity Association

Chinese (Uighur in Xinjiang)

Population

Study Design

Common polymorphism was examined in centenarians (n=42), 90-year-old people (n=102), 65-70-year-old people (n=70) and controls(n=53).

Conclusions

The frequencies of genotype E3/4 and E4, E3 alleles in the centenarian group were significantly lower than those in controls, whereas the frequencies of genotype E2/3 and E2 allele in the centenarian group were significantly higher than those in controls.

Indentifier

Reference

Study 14

Longevity Association

The association of sex and age with the occurrence of APOE genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians was examined

Population

Italian (Southern)

Study Design

Conclusions

A higher E2 frequency was observed in men aged 60-90 years and in centenarians

Indentifier

Reference

Study 15

Longevity Association

Polymorphisms were studied in a sample of 538 Colombian subjects (aged 18-106 years)

Population

Columbian

Study Design

Conclusions

There were no differences between young and old subjects

Indentifier

APOE

Reference

Study 16

Longevity Association

The prevalence of genotypes in 80 healthy aged individuals (>80 years) and 391 adults (median age 43 years) was examined

Population

Greek

Study Design

Conclusions

Genotypes were comparable in both groups with the exception of E3/3 and E3/4, which were significantly higher and lower, respectively, in aged individuals. The epsilon2 and epsilon3 allele frequencies were not different between the groups. The epsilon4 allele was significantly less frequent in aged individuals compared to controls.

Indentifier

Reference

Study 17

Longevity Association

American (Georgia and Louisiana populations from African and European origin)

Population

Study Design

Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)

Conclusions

APOE was associated with longevity

Indentifier

APOE

Reference

Study 18

Longevity Association: Significant
Population: Italian
Study Design: Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions: rs429358 (APOE) was associated with longevity in the replication population
Indentifier

Study 19

Longevity Association

APOE genotypes were assessed in 114 nonagenarians and 2071 younger controls (30-65 years)

Population

Irish (Belfast)

Study Design

Conclusions

The E4 allele was reduced in the nonagenarian group (X(2)=11.1; P=0.0006), the E3 unchanged and E2 frequency was increased (X(2)=4.0; P=0.047). Longevity is negatively associated with the E4 allele and may be associated with carriage of E2.

Indentifier

Reference

Study 20

Longevity Association

the relationship between APOE and longevity was analyzed among 1562 Han Chinese (ages ranged from 20-108 years, 246 female and 1316 male)

Population

Chinese (Han)

Study Design

Conclusions

The allele frequency of APOE*4 in the very old age group (> or = 85 years) was significantly different from that in the youth (20-39 years), middle (40-59 years) and old (60-84 years) age group (2.5% vs 8.4, 7.9 or 7.6%; P < 0.05), respectively

Indentifier

Reference

Study 21

Longevity Association

American (Georgia and Louisiana populations from African and European origin)

Population

Study Design

Conclusions

An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.

Indentifier

APOE

Reference

Study 26

Longevity Association

Common polymorphism was examined in centenarians (n = 338) and in adults aged 20-70 years

Population

French

Study Design

Conclusions

E4 allele was significantly less frequent in centenarians than in controls, while the frequency of the E2 allele was significantly increased

Indentifier