LongevityMap Gene

Gene details

HGNC symbol: AGT
Aliases: ANHU; SERPINA8
Common name: angiotensinogen
Description: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 1q42.2
UCSC Genome Browser: View 1q42.2 on the UCSC genome browser
OMIM: 106150
Ensembl: ENSG00000135744
UniProt/Swiss-Prot: ANGT_HUMAN
Entrez Gene: 183
UniGene: 19383
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: agt
Mus musculus: Agt
Rattus norvegicus: Agt

In other databases

CellAge

This gene is present as AGT

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association

Non-significant

Population

Study Design

M/T235 SNP was examined in 187 centenarians and 201 controls (20-64 years)

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Population

Study Design

M/T235 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)

Conclusions

Significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele

Indentifier

Reference