LongevityMap Gene
Gene details
- HGNC symbol
- ADARB2
- Aliases
- RED2; ADAR3
- Common name
- adenosine deaminase, RNA specific B2 (inactive)
- Description
- This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
- OMIM
- 602065
- Ensembl
- ENSG00000185736
- UniProt/Swiss-Prot
- RED2_HUMAN
- Entrez Gene
- 105
- UniGene
- 586663
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Italian, Ashkenazi Jewish and Japanese
- Study Design
- Association study of RNA editing genes ADARB1 and ADARB2 with exceptional longevity in the New England Centenarian Study (NECS), with more than 1,500 US individuals of primarily North European ancestry, the Southern Italian Centenarian Study (SICS), the Ashkenazi Jewish Centenarian Study (AJCS), a study of approximately 300 nonagenarians and centenarians, and the Japanese Centenarian Study (JCS), a study of Japanese centenarians which focuses on \semi-supercentenarians\" subjects living past 105 years"
- Conclusions
- SNPs in the RNA editing genes ADARB1 and ADARB2 were significantly associated with extreme old age in the New England Centenarian Study. These findings were replicated in different genetic backgrounds (Italian, Ashkenazi Jewish and Japanese) with mixed results.
- Indentifier
- rs10903420
- Reference