LongevityMap Gene
Gene details
- HGNC symbol
- ADA2
- Aliases
- PAN; ADGF; CECR1; IDGFL; SNEDS
- Common name
- adenosine deaminase 2
- Description
- This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- Cytogenetic Location
- 22q11.1
- UCSC Genome Browser
- View 22q11.1 on the UCSC genome browser
- OMIM
- 607575
- Ensembl
- ENSG00000093072
- UniProt/Swiss-Prot
- A0A087X0I3_HUMAN
- Entrez Gene
- 51816
- UniGene
- 170310
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- cecr1a
- Danio rerio
- cecr1b
- Drosophila melanogaster
- Msi
- Drosophila melanogaster
- Adgf-C
- Drosophila melanogaster
- Adgf-D
- Drosophila melanogaster
- Adgf-B
- Drosophila melanogaster
- Adgf-A
- Drosophila melanogaster
- Adgf-E
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- 884 unrelated healthy individuals (age range 10-106 years, 400 males and 484 females) from central Italy were studied
- Conclusions
- An increased frequency of ADA*2 carriers was found in males aged 80-85, and a decreased frequency in males over 85 (v2 = 13.93; df = 3; P = 0.003); significant differences among the age groups was not found in females
- Indentifier
- ADA*2
- Reference