LongevityMap Gene

I/D polymorphism was examined in centenarians (n = 338) and in adults aged 20-70 years

Population

French

Study Design

Conclusions

A variant of ACE which predisposes to coronary heart disease was more frequent in centenarians with a significant increase of the homozygous genotype

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Reference

Study 2

Longevity Association

I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years

Population

English (Cambridge)

Study Design

Conclusions

The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women.

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Reference

Study 3

Longevity Association

Population

ACE (I/D) polymorphism was examined in 10,150 subjects from 20 to >80 years-old

Study Design

Conclusions

The relative frequency of the D allele did not change as a function of age

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Reference

Study 4

Longevity Association

I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women)

Population

French

Study Design

Conclusions

Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor a significant correlation with cardiovascular pathology

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Reference

Study 5

Longevity Association

Population

I/D polymorphism was examined in 187 centenarians and 201 controls (20-64 years)

Study Design

Conclusions

No significant differences relative to longevity were found

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Reference

Study 6

Longevity Association

I/D polymorphism was determined in 648 subjects >85 years-old. Genotype distributions in a subset of 356 elderly subjects were compared to 250 young subjects. Mortality of elderly subjects was also followed for 10 years.

Population

Dutch

Study Design

Conclusions

The ACE genotype distributions were similar in elderly and young subjects. No associations with mortality were found.

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Reference

Study 7

Longevity Association

I/D polymorphism was examined in 560 centenarians and 560 adult controls

Population

French

Study Design

Conclusions

No association was observed between ACE allele frequencies or genotype and longevity

Indentifier

Reference

Study 8

Longevity Association

I/D polymorphism was examined in 2689 healthy Caucasians: 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females)

Population

American (Caucasian)

Study Design

Conclusions

No statistically significant decrease in genotype or allele frequency was observed among carriers of ACE D

Indentifier

Reference

Study 9

Longevity Association

Population

The I/D polymorphism was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)

Study Design

Conclusions

No significant differences relative to longevity were found

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Reference

Study 10

Longevity Association

Chinese (Uighur, Kazakh and Han in Xinjiang)

Population

Study Design

I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years.

Conclusions

Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly.

Indentifier

Reference

Study 11

Longevity Association

I/D polymorphism was examined in 101 long-lived subjects and in a group of 494 younger persons

Population

Polish

Study Design

Conclusions

No connection was found between ACE polymorphism and long-life

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Reference

Study 12

Longevity Association

Population

The cognitive skills of 684 twins aged 73+ years were examined in relation to a polymorphic 287 bp fragment in the ACE gene that can be present in the insertion (I) variant and absent in the deletion (D) variant

Study Design

Conclusions

Neither physical nor cognitive performance was associated with the ACE genotype. Having the D allele, however, improved the chances of survival.

Indentifier

Reference

Study 13

Longevity Association

I/D polymorphism was examined in 103 centenarians (13 men and 90 women) and in 7232 apparently healthy adults (4100 men and 3132 women)

Population

Korean

Study Design

Conclusions

The frequencies of genotypes and alleles of the centenarians were not significantly different from those of the control groups. There was also a lack of association between the presence of the D allele and dementia status.

Indentifier

Reference

Study 14

Longevity Association

Italian, French and Danish

Population

Study Design

I/D polymorphism was examined in 82 centenarians and 252 middle-aged, unrelated subjects or volunteers

Conclusions

No statistically significant differences were found in ACE genotype or allele frequencies between centenarians and controls

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Reference

Study 15

Longevity Association

Brazilian of European and Japanese origin

Population

Study Design

I/D polymorphism was examined in 834 persons aged 10-104 years

Conclusions

An association between the DD genotype and D allele and age was observed in the European group only. The ACE polymorphism-age association occurred at age >60 years in the European population with decreasing II frequency.

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Reference

Study 16

Longevity Association

I/D polymorphism was examined in 97 elderly subjects and control group aged 25-64

Population

Russian (Novosibirsk)

Study Design

Conclusions

Frequency of D/D genotype among senile and long-living men was significantly lower than in men 55-64 years of age. A similar decrease of this gene frequency was also found in women of the same age.

Indentifier

Reference

Study 17

Longevity Association

Chinese (Uighur in Xinjiang)

Population

Study Design

I/D polymorphisms of ACE gene were examined in 42 centenarians, 102 people aged 90-99, 70 people aged 65-70, and 53 cases of natural death aged 65-70 used as controls

Conclusions

The frequency rates of genotype D/D and D alleles were significantly higher in the centenarian group than in the controls

Indentifier

Reference

Study 18

Longevity Association

The association of sex and age with the occurrence of ACE genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians was examined

Population

Italian (Southern)

Study Design

Conclusions

A significant association of D allele and age was observed in centenarians

Indentifier

Reference

Study 19

Longevity Association

Polymorphisms in the ACE gene were analyzed in a sample of 538 subjects Colombian subjects (18-106 years)

Population

Columbian

Study Design

Conclusions

A significant decrease in DD genotype (24 vs. 16%) was observed between young and old subject groups (mean age: 45 vs. 77 years). The ACE DD genotype and D allele decrease was significant only in women.

Indentifier

Reference

Study 20

Longevity Association

The genotype and allele frequency distribution of I/D polymorphisms were analyzed in 235 Italian patients with sporadic Alzheimer disease, 153 with familial Alzheimer disease, 192 healthy controls and 111 centenarians

Population

Italian

Study Design

Conclusions

There were no significant differences in ACE genotypes or allele frequencies in all the studied groups. Centenarians showed the highest allele D frequency, although the value was not statistically significant.

Indentifier

Reference

Study 21

Longevity Association: Significant
Population: Greek
Study Design: 307 individuals (190 nonagenarians, 12 centenarians and 105 middle-aged controls) were genotyped for ACE, NFkB, and CETP genetic variants
Conclusions: The I carriers of ACE I/D had higher frequency in centenarians than in nonagenarians (P = 0.016). And higher than in controls(P = 0.045).
Indentifier

Study 22

Longevity Association

The contribution to ankle-brachial index, development of cardiovascular disease and mortality of ACE I/D was examined in 4000 individuals( >65 y) during a four years follow-up study

Population

Chinese

Study Design

Conclusions

Although D/D genotype was associated with mortality only in men, the D/D genotype had the greatest reduction in mean ankle-brachial index after adjusting for confounding factors and it also more common among women who developed hypertension or myocardial infarction. There are gender differences in the relationship between D/D genotype and cardiovascular diseases.

Indentifier