LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: German
Study Design: Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions: FOXO3A and EXO1 were not significantly associated with longevity

HGNC symbol: EXO1
Aliases: HEX1; hExoI
Common name: exonuclease 1
Description: This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 20
OMIM: 606063
Ensembl: ENSG00000174371
UniProt/Swiss-Prot: A8K5H6_HUMAN
Entrez Gene: 9156
UniGene: 498248
HapMap: View on HapMap

GenAge model organism genes

CellAge gene expression

HGNC symbol: FOXO3
Aliases: FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
Common name: forkhead box O3
Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 101
OMIM: 602681
Ensembl: ENSG00000118689
UniProt/Swiss-Prot: FOXO3_HUMAN
Entrez Gene: 2309
UniGene: 220950
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

CellAge

Nebel et al. (2011)