LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Italian, Ashkenazi Jewish and Japanese
- Study Design
- Association study of RNA editing genes ADARB1 and ADARB2 with exceptional longevity in the New England Centenarian Study (NECS), with more than 1,500 US individuals of primarily North European ancestry, the Southern Italian Centenarian Study (SICS), the Ashkenazi Jewish Centenarian Study (AJCS), a study of approximately 300 nonagenarians and centenarians, and the Japanese Centenarian Study (JCS), a study of Japanese centenarians which focuses on \semi-supercentenarians\" subjects living past 105 years"
- Conclusions
- SNPs in the RNA editing genes ADARB1 and ADARB2 were significantly associated with extreme old age in the New England Centenarian Study. These findings were replicated in different genetic backgrounds (Italian, Ashkenazi Jewish and Japanese) with mixed results.
Variants (13)
1.
- Identifier
- rs10903420
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
2.
- Identifier
- rs1007147
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
3.
- Identifier
- rs2805562
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
4.
- Identifier
- rs884949
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
5.
- Identifier
- rs2805533
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
6.
- Identifier
- rs2387653
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
7.
- Identifier
- rs2805535
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
8.
- Identifier
- rs2805543
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
9.
- Identifier
- rs3898610
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
10.
- Identifier
- rs1533484
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
11.
- Identifier
- rs2676192
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
12.
- Identifier
- rs2387952
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
13.
- Identifier
- rs17294019
- Cytogenetic Location
- 10p15.3
- UCSC Genome Browser
- View 10p15.3 on the UCSC genome browser
Gene details
- HGNC symbol
- ADARB2
- Aliases
- RED2; ADAR3
- Common name
- adenosine deaminase, RNA specific B2 (inactive)
- Description
- This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 12
- OMIM
- 602065
- Ensembl
- ENSG00000185736
- UniProt/Swiss-Prot
- RED2_HUMAN
- Entrez Gene
- 105
- UniGene
- 586663
- HapMap
- View on HapMap