LongevityMap variant group

Entry Details

Longevity Association: Significant
Population: Italian, Ashkenazi Jewish and Japanese
Study Design: Association study of RNA editing genes ADARB1 and ADARB2 with exceptional longevity in the New England Centenarian Study (NECS), with more than 1,500 US individuals of primarily North European ancestry, the Southern Italian Centenarian Study (SICS), the Ashkenazi Jewish Centenarian Study (AJCS), a study of approximately 300 nonagenarians and centenarians, and the Japanese Centenarian Study (JCS), a study of Japanese centenarians which focuses on \semi-supercentenarians\" subjects living past 105 years"
Conclusions: SNPs in the RNA editing genes ADARB1 and ADARB2 were significantly associated with extreme old age in the New England Centenarian Study. These findings were replicated in different genetic backgrounds (Italian, Ashkenazi Jewish and Japanese) with mixed results.

HGNC symbol: ADARB1
Aliases: RED1; ADAR2; DRABA2; DRADA2
Common name: adenosine deaminase, RNA specific B1
Description: This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 4
OMIM: 601218
Ensembl: ENSG00000197381
UniProt/Swiss-Prot: RED1_HUMAN
Entrez Gene: 104
UniGene: 474018
HapMap: View on HapMap

Sebastiani et al. (2009)