LongevityMap variant

Entry Details

Longevity Association
Significant
Population
English (Cambridge)
Study Design
Allele and genotype frequencies at Hpa1 RFLP were examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years
Conclusions
Allele and genotype frequencies were significantly different in the elderly women compared to the younger sample. No difference was observed in the elderly men.
Identifier
APOC1
Cytogenetic Location
19q13.32
UCSC Genome Browser
View 19q13.32 on the UCSC genome browser

Gene details

HGNC symbol
APOC1
Aliases
Apo-CI; ApoC-I; apo-CIB; apoC-IB 
Common name
apolipoprotein C1 
Description
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Other longevity studies of this gene
3
OMIM
107710
Ensembl
ENSG00000130208
UniProt/Swiss-Prot
A0A024R0T8_HUMAN
Entrez Gene
341
UniGene
110675
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Apoc1
Rattus norvegicus
Apoc1
Rattus norvegicus
LOC100910181
Rattus norvegicus
Apoc1
Rattus norvegicus
Apoc1

In other databases

CellAge gene expression
  • This gene is present as APOC1

References

Galinsky et al. (1997)

Other variants which are also part of this study