LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Danish
Study Design: The cognitive skills of 684 twins aged 73+ years were examined in relation to a polymorphic 287 bp fragment in the ACE gene that can be present in the insertion (I) variant and absent in the deletion (D) variant
Conclusions: Neither physical nor cognitive performance was associated with the ACE genotype. Having the D allele, however, improved the chances of survival.

Identifier: I/D
In Other Studies (IDs): 6 13 18 28 37 45 53 62 63 78 85 98 123 126 130 162 222 225 228 288
Cytogenetic Location: 17q23.3
UCSC Genome Browser: View 17q23.3 on the UCSC genome browser

HGNC symbol: ACE
Aliases: DCP; ACE1; DCP1; CD143
Common name: angiotensin I converting enzyme
Description: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Other longevity studies of this gene: 32
OMIM: 106180
Ensembl: ENSG00000159640
UniProt/Swiss-Prot: ACE_HUMAN
Entrez Gene: 1636
UniGene: 298469
HapMap: View on HapMap

GenAge model organism genes

Frederiksen et al. (2003)