LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Northern)
- Study Design
- The -124 and 169 position SNPs were examined in 50 centenarians and 86 young controls
- Conclusions
- Genotype and allele distribution for both polymorphisms were similar in controls and centenarians
- HGNC symbol
- FASLG
- Aliases
- APTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1
- Common name
- Fas ligand
- Description
- This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
- OMIM
- 134638
- Ensembl
- ENSG00000117560
- UniProt/Swiss-Prot
- Q53ZZ1_HUMAN
- Entrez Gene
- 356
- UniGene
- 2007
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- faslg
- Mus musculus
- Fasl
- Rattus norvegicus
- Faslg
Pinti et al. (2002)
Other variants which are also part of this study
