LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Exon 9 AvaII RFLP polymorphism was examined in 219 centenarians (72 males and 147 females) and 256 (controls 20-70 years, 119 males and 137 females)
- Conclusions
- No significant difference between centenarians and controls was observed
- HGNC symbol
- IGF2
- Aliases
- GRDF; IGF-II; PP9974; C11orf43
- Common name
- insulin like growth factor 2
- Description
- This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
- Other longevity studies of this gene
- 6
- OMIM
- 147470
- Ensembl
- ENSG00000167244
- UniProt/Swiss-Prot
- E3UN46_HUMAN
- Entrez Gene
- 3481
- UniGene
- 272259
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- igf2b
- Danio rerio
- igf2a
- Mus musculus
- Igf2
- Rattus norvegicus
- Igf2
- GenAge human genes
- This gene is present as IGF2
De Luca et al. (2001)
Other variants which are also part of this study
