LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- M/T235 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)
- Conclusions
- Significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele
- HGNC symbol
- AGT
- Aliases
- ANHU; SERPINA8
- Common name
- angiotensinogen
- Description
- The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 106150
- Ensembl
- ENSG00000135744
- UniProt/Swiss-Prot
- ANGT_HUMAN
- Entrez Gene
- 183
- UniGene
- 19383
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- agt
- Mus musculus
- Agt
- Rattus norvegicus
- Agt
- CellAge
- This gene is present as AGT
Tan et al. (2001)
Other variants which are also part of this study
