LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian (Central)
Study Design: Functional SNPs have been determined for 1071 unrelated healthy individuals (502 males and 569 females) from Central Italy, 18-106 years old, divided into three gender-specific age classes defined according to demographic information and accounting for the different survivals between sexes. The categories for men were: individuals <66 years old, individuals 66-88 years old, and individuals > 88 years old. The categories for women were: individuals <73 years old, individuals 73-91 years old, and individuals > 91 years old.
Conclusions: Single-locus analysis showed that when comparing all 3 age categories only ADA 22G>A (rs73598374) is significantly associated with human life-expectancy in males

HGNC symbol: ADA
Aliases
Common name: adenosine deaminase
Description: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 1
OMIM: 608958
Ensembl: ENSG00000196839
UniProt/Swiss-Prot: A0A0S2Z381_HUMAN
Entrez Gene: 100
UniGene: 654536
HapMap: View on HapMap

GenAge model organism genes

Napolioni et al. (2011)