LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian
Study Design: 884 unrelated healthy individuals (age range 10-106 years, 400 males and 484 females) from central Italy were studied
Conclusions: An increased frequency of ADA*2 carriers was found in males aged 80-85, and a decreased frequency in males over 85 (v2 = 13.93; df = 3; P = 0.003); significant differences among the age groups was not found in females

HGNC symbol: ADA2
Aliases: PAN; ADGF; CECR1; IDGFL; SNEDS
Common name: adenosine deaminase 2
Description: This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OMIM: 607575
Ensembl: ENSG00000093072
UniProt/Swiss-Prot: A0A087X0I3_HUMAN
Entrez Gene: 51816
UniGene: 170310
HapMap: View on HapMap

Napolioni and Lucarini (2010)