LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American (Caucasian)
Study Design: Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
Conclusions: Although no genome-wide associations were significant, several SNPs in some previously associated genes with longevity had suggestive associations with age at death or morbidity-free survival at age 65 years. Noteworthy results included two SNPs within FOXO1A (rs10507486 and rs4943794) associated with age at death.

HGNC symbol: PPP1R9A
Aliases: NRB1; NRBI; Neurabin-I
Common name: protein phosphatase 1 regulatory subunit 9A
Description: This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Other longevity studies of this gene: 5
OMIM: 602468
Ensembl: ENSG00000158528
UniProt/Swiss-Prot: A4D1I0_HUMAN
Entrez Gene: 55607
UniGene: 21816
HapMap: View on HapMap

Lunetta et al. (2007)